Karen M. Puopolo, M.D., Ph.D. is a neonatologist who specializes in neonatal infectious diseases.  Dr. Puopolo received her undergraduate degree in physics from Yale University, and her M.D. as well as a Ph.D. in molecular physiology from the Tufts University School of Medicine and Graduate School of Biomedical Sciences. She completed Pediatric residency and Neonatal-Perinatal fellowship training at Boston Children’s Hospital. Upon completing fellowship, Dr. Puopolo was appointed to the faculty of Harvard Medical School and joined the staff of the Brigham and Women’s Hospital and the Channing Laboratory, where she was an attending neonatologist and investigator from 2000-2014.  Dr. Puopolo began her neonatal research career as a laboratory-based scientist investigating mechanisms of virulence in Group B Streptococcus. More recently her research has focused on the epidemiology of neonatal infection, with an emphasis on risk assessment and antibiotic stewardship.  In collaboration with Dr. Gabriel Escobar, she developed the Neonatal Early-Onset Sepsis Calculator, a clinical decision tool for sepsis risk assessment among term infants. Dr. Puopolo is currently a Professor of Pediatrics on the faculty of the University of Pennsylvania Perelman School of Medicine.  She is a member of the Division of Neonatology at Children’s Hospital of Philadelphia, and Chief of the Section on Newborn Medicine at Pennsylvania Hospital.  She has been funded by the National Institutes of Health and the Centers for Disease Prevention for her studies in neonatal infection. Dr. Puopolo is an active member of the American Academy of Pediatrics, contributing to practice guidance for neonatal sepsis, GBS prevention, perinatal COVID-19, congenital CMV infection and neonatal antibiotic stewardship. She has served as faculty for the neonatal quality collaborative Vermont-Oxford Network, served as an Associate Editor at Pediatrics, is a Section Editor at UpToDate, and currently serves as Chair of the AAP Committee on Fetus and Newborn.