OMB No. 0925-0001 and 0925-0002 (Rev. 10/2021 Approved Through 01/31/2026)

NAME: Sanket D Shah, MD

POSITION TITLE:     Associate Professor of Pediatrics, Division of Neonatology,

University of Florida, College of Medicine-Jacksonville

EDUCATION/TRAINING

I have been fortunate to develop my skills through various missions in the field of neonatology, including roles as a clinical researcher, medical director of a Level III NICU, and educator and mentor for medical students and residents. My greatest passion lies in expanding my knowledge in neonatology, which will help us reduce morbidity among high-risk infants through well-designed clinical trials. I have a broad background in neonatology, with a specific interest in clinical research involving premature infants. During my fellowship, I participated in multiple projects and published findings that demonstrated an association between improved nutritional outcomes and early human milk fortification. At the University of Florida, I have continued to conduct numerous studies and publish manuscripts in peer-reviewed journals. Additionally, I have collaborated with numerous physician-scientists across the country on various clinical studies. Over the years, I have been successful in recruiting patients for multiple clinical trials, ensuring protocol adherence, and promptly reporting any events alongside the research team.

B.        Positions and Honors

Academic Appointments

2015–2023      Assistant Professor of Pediatrics, University of Florida COM, Jacksonville, Florida

2023–2026      Associate Professor of Pediatrics, University of Florida COM,  Jacksonville, Florida

Service Appointments

2015–2026   Medical Staff, UF Health, Jacksonville, Florida

2015–Present   Medical Staff, Wolfson Children’s Hospital, Jacksonville, Florida

2016–2023   Medical Staff, Flagler Hospital, St Augustine, Florida

COMMITTEES AND OFFICES HELD: 

2025 – 2026                Pediatric Faculty Council alternate representative

2025 – 2026                Chair of Pediatric Performance Improvement Committee, UF health

2023 – 2026                Medical Director, University of Florida NICU

2023 – 2026                Medical Student NICU elective director, University of Florida, Jacksonville

2021– 2026                             Faculty Search Committee Member, University of Florida Health Jacksonville

2019 - 2022                             Alternate member, Institutional review board, University of Florida    

2014-2015                               TeCAN (Trainee and early Career Neonatologist) Program Representative

                                                            of District IV-AAP Section of Perinatology

2014-2015                               Chief Fellow, UTHSC, Division of Neonatology, Department of Pediatrics

2014-2015                               Perinatal Conference Coordinator – Fellow Representative

2011–2013                  Pediatric Program Representative in Graduate Medical Education, Marshfield Clinic, WI

Other Experience and Professional Memberships

2007–Present    Medical Council of India

2009–Present  American Academy of Pediatrics, Fellow

2014–2022        Instructor, Neonatal Resuscitation Program, American Academy of Pediatrics

Honors

2015                         Pediatric Academic Society Travel Award for Young Investigator’s clinical research

San Diego, CA April 2015

2023                               Exemplary Teacher Award, University of Florida

C. Contribution to Science

1. My introduction to clinical research began during my pediatric residency, where I learned how to formulate appropriate research questions and utilize various databases. During my fellowship under the guidance of Dr. Ajay Talati at the University of Tennessee, I was trained for a career in nutrition. My focus was on fortifying human milk earlier than the standard of care, and I conducted a randomized controlled trial to assess feeding tolerance in preterm infants. I received an extramural research grant and a Travel Award for Young Investigators for my clinical trial. My interest in nutrition continued as I participated in the Vermont Oxford Network (VON) collaborative project.

• Shah S, Murali H. Steroid-responsive encephalopathy and autoimmune thyroiditis in a young boy. Pediatr Neurol 2011; 45(2):132-4.

• Shah S, Gross J, Stewart CT. A case report of meningococcal disease in a neonate, WMJ 2013;112(1):28-30.
• Shah SD, Talati AJ, Elabiad MT, Dhanireddy R, Pourcyrous M. Preterm infantscan mount appropriate C-reactive protein responses to early onset sepsis, Am J Perinatol 2015;32(13):1281-6.

• Shah S, Dereddy N, Jones T, Dhanireddy R, Talati AJ: Early versus delayed human milk fortification in very low birth weight infants - a randomized controlled trial, J Pediatr 2016; 174 (1):126-131.
• Shah S, Apostolakis-Kyrus K, Talati AJ: Maternal labetolol treatment and its effects on a preterm infant. J Investig Med 2014;63(2):408 (#295).

• Thoni N, Shah S, Skeen A, Talati A: Comparison of outcomes of very low birth weight infants fed human milk fortified with liquid acidified human milk fortifier versus powdered fortifier. J Investig Med 2014; 63(2):447 (#423).

2. After completing my fellowship, I moved to the University of Florida in Jacksonville to advance my career in clinical research focused on neonatal outcomes, benefiting from a larger geographical area.  I continued to pursue my interest in nutrition by developing a standardized feeding protocol for premature infants, which resulted in a published study emphasizing the importance of standardization in feeding practices. Additionally, I created an innovative approach to managing patent ductus arteriosus by combining two medications and conducted a pilot trial to test this approach. In collaboration with the Department of Pharmacy, we also published our findings on the pharmacokinetics and pharmacodynamics of this combination therapy.

• Shah SD, Booth N, Nandula P, Makker K, Cortez J, Sharma R, Smotherman C, Hudak ML. Effects of standardized feeding protocol on growth velocity and necrotizing enterocolitis in extremely low birth weight infants. J Perinatol. 2021 Jan;41(1):134-139
• Shah SD, Makker K, Nandula P, Smotherman C, Kropf A, Hudak ML. Effectiveness of Dual Medication Therapy (Oral Acetaminophen and Oral Ibuprofen) for the Management of Patent Ductus Arteriosus in Extremely Premature Infants: A Feasibility Trial. Am J Perinatol. 2022 Sep;39(12):1326-1333
• Almoslem M, Shah SD, Vozmediano V, Guzy S, Kim S, Hudak ML, Schmidt S. Pharmacokinetic and Pharmacodynamic Analysis of Acetaminophen and Ibuprofen Dual Therapy for Patent Ductus Arteriosus Closure in Preterm Neonates Less Than 29 Weeks' Gestation. J Clin Pharmacol. 2023 Nov 27. doi: 10.1002/jcph.2386. Epub ahead of print. PMID: 38015103.

3. In Jacksonville, I collaborated with Kartikeya Makker and Sireesha Nandula on a clinical trial that compared two different modes of non-invasive ventilation in preterm infants. Together, we successfully published several manuscripts. Additionally, while working with other colleagues across the country, we conducted systematic reviews and meta-analyses.

• Makker, K, Cortez, J, Jha, K, Shah SD et al. Comparison of extubation success using noninvasive positive pressure ventilation (NIPPV) versus noninvasive neurally adjusted ventilatory assist (NI-NAVA). J Perinatol. 2020 Aug;40(8):1202-1210
• Shah SD, Makker K, Zhang M, Harnett S, Aziz KB, Hudak ML. Dual medication therapy (acetaminophen and ibuprofen) for the management of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. J Perinatol. 2022 Dec;42(12):1654-1661. doi: 10.1038/s41372-022-01500-8. Epub 2022 Aug 25. PMID: 36008521.
• Nandula PS, Shah SD. Persistent Pulmonary Hypertension Of The Newborn. 2022 Aug 5. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 36256747.

• Logan JW, Nath S, Shah SD, Nandula PS, Hudak ML. Respiratory support strategies in the management of severe, longstanding bronchopulmonary dysplasia. Front Pediatr. 2022 Nov 14; 10:1016204. doi: 10.3389/fped.2022.1016204. PMID: 36452354; PMCID: PMC9704771.
• Nandula PS, Buckelew A, Cortez J, Snyder D, Smith T, Aderhold A, Meyers J, Garber M, Shah SD, Webb LK, Hudak ML. A quality improvement initiative to reduce the time to initial maternal visit in the neonatal intensive care unit. J Perinatol. 2023 Jul 20. doi: 10.1038/s41372-023-01726-0. Epub ahead of print. PMID: 37474754.

D. Research Support (completed)

            Aerohgen Pharma                                                                               David Durand (PI)                                                                  6/9/2020 -        11/10/2024     

“A Partially Blind, Randomized, Controlled, Parallel-Group Dose Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFactTM (SF-RI 1 surfactant for inhalation combined with a dedicated drug delivery system) in Preterm Infants at Risk of Worsening Respiratory Distress Syndrome”

The goal of the study was to determine the safety and efficacy of surfactant and its delivery system in pretern infants

Role: Local PI

Mead Johnson Nutrition                           Shah, Sanket (PI)                                                                                04/01/2014 – 10/31/2015

“Early versus Delayed Human Milk Fortification in Very Low Birth Weight Infants–A Randomized Controlled Trial”

The goal of this project was to evaluate feeding tolerance of human milk fortification at two different feeding volumes in preterm infants.

Role: PI

UF Dean’s Fund Research Grant      Shah, Sanket (PI)                                                     10/01/2017 – 09/30/2018                                                                                                          “Combination of acetaminophen and ibuprofen in the management of patent ductus arteriosus in premature infants: A Pilot Study”

The goal of this project was to evaluate the efficacy and safety of dual therapy in the management of patent ductus arteriosus

Role: PI

UF Dean’s Fund Research Grant      Makker, Kartikeya (PI)                       10/01/2017 – 09/30/2018                         

“Comparison of primary extubation failure between noninvasive positive pressure ventilation (NIPPV) and noninvasive neural access ventilatory assist (NI-NAVA): A Randomized Pilot Study”

      The goal of this project was to evaluate the extubation success with two modes of non-invasive ventilation.

Role: Co-Investigator